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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1849 1
1858 1
1867 1
1875 1
1890 3
1905 1
1906 1
1921 1
1923 1
1925 1
1929 1
1930 1
1931 1
1933 1
1934 2
1936 1
1939 1
1944 1
1945 42
1946 187
1947 140
1948 107
1949 108
1950 152
1951 126
1952 157
1953 208
1954 189
1955 187
1956 153
1957 234
1958 223
1959 188
1960 146
1961 192
1962 229
1963 351
1964 572
1965 417
1966 349
1967 500
1968 536
1969 621
1970 632
1971 640
1972 657
1973 686
1974 679
1975 836
1976 808
1977 868
1978 895
1979 953
1980 1044
1981 1045
1982 1003
1983 1265
1984 1199
1985 1283
1986 1367
1987 1271
1988 1385
1989 1576
1990 1684
1991 1710
1992 1955
1993 2133
1994 1925
1995 1978
1996 1959
1997 2158
1998 2337
1999 2524
2000 2660
2001 2648
2002 2741
2003 2900
2004 3031
2005 3295
2006 3499
2007 3749
2008 3862
2009 4091
2010 4375
2011 4788
2012 5108
2013 5448
2014 5553
2015 5549
2016 5708
2017 5740
2018 5898
2019 6214
2020 6978
2021 7764
2022 7345
2023 7215
2024 2814

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151,803 results

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Page 1
Antiepileptic Drugs and Liver Disease.
Vidaurre J, Gedela S, Yarosz S. Vidaurre J, et al. Pediatr Neurol. 2017 Dec;77:23-36. doi: 10.1016/j.pediatrneurol.2017.09.013. Epub 2017 Sep 22. Pediatr Neurol. 2017. PMID: 29097018 Review.
Acute, symptomatic seizures or epilepsy may complicate the course of hepatic disease. Choosing the most appropriate antiepileptic drug in this setting represents a difficult challenge, as most medications are metabolized by the liver. ...
Acute, symptomatic seizures or epilepsy may complicate the course of hepatic disease. Choosing the most appropriate antiepileptic …
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Nevitt SJ, Sudell M, Cividini S, Marson AG, Tudur Smith C. Nevitt SJ, et al. Cochrane Database Syst Rev. 2022 Apr 1;4(4):CD011412. doi: 10.1002/14651858.CD011412.pub4. Cochrane Database Syst Rev. 2022. PMID: 35363878 Free PMC article. Review.
Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Most people with epilepsy are treated with a single antiepileptic …
Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission …
Therapeutic Drug Monitoring of Antiepileptic Drugs in Women with Epilepsy Before, During, and After Pregnancy.
Arfman IJ, Wammes-van der Heijden EA, Ter Horst PGJ, Lambrechts DA, Wegner I, Touw DJ. Arfman IJ, et al. Clin Pharmacokinet. 2020 Apr;59(4):427-445. doi: 10.1007/s40262-019-00845-2. Clin Pharmacokinet. 2020. PMID: 31912315 Review.
During pregnancy, the pharmacokinetics of an antiepileptic drug is altered because of changes in the clearance capacity and volume of distribution. ...If the antiepileptic drug concentration changes more than 25% compared with the reference concentrati …
During pregnancy, the pharmacokinetics of an antiepileptic drug is altered because of changes in the clearance capacity and vo …
Topiramate: a new antiepileptic drug.
Markind JE. Markind JE. Am J Health Syst Pharm. 1998 Mar 15;55(6):554-62. doi: 10.1093/ajhp/55.6.554. Am J Health Syst Pharm. 1998. PMID: 9544331 Review.
A sulfamate-substituted monosaccharide, it is structurally distinct from other antiepileptic agents. Topiramate acts by blocking the spread of seizures. Oral topiramate has high bioavailability and low protein binding, and as monotherapy its half-life permits …
A sulfamate-substituted monosaccharide, it is structurally distinct from other antiepileptic agents. Topiramate acts by blocking the …
Topiramate: a new antiepileptic drug.
Privitera MD. Privitera MD. Ann Pharmacother. 1997 Oct;31(10):1164-73. doi: 10.1177/106002809703101010. Ann Pharmacother. 1997. PMID: 9337443 Review.
OBJECTIVE: To review proposed mechanisms of action, clinical pharmacology, efficacy, safety, and tolerability of the antiepileptic drug (AED) topiramate. METHODS: All available data from the clinical development program--published and unpublished data (provid …
OBJECTIVE: To review proposed mechanisms of action, clinical pharmacology, efficacy, safety, and tolerability of the antiepileptic …
Summary of recommendations for the management of infantile seizures: Task Force Report for the ILAE Commission of Pediatrics.
Wilmshurst JM, Gaillard WD, Vinayan KP, Tsuchida TN, Plouin P, Van Bogaert P, Carrizosa J, Elia M, Craiu D, Jovic NJ, Nordli D, Hirtz D, Wong V, Glauser T, Mizrahi EM, Cross JH. Wilmshurst JM, et al. Epilepsia. 2015 Aug;56(8):1185-97. doi: 10.1111/epi.13057. Epub 2015 Jun 30. Epilepsia. 2015. PMID: 26122601 Free article. Review.
Infantile encephalopathies should have rapid introduction and increment of antiepileptic drug dosage (expert opinion, level U recommendation). There is no high level evidence to support any particular current agents for use in infants with seizures. For focal …
Infantile encephalopathies should have rapid introduction and increment of antiepileptic drug dosage (expert opinion, level U …
Topiramate: Comprehensive profile.
Khalil NY, AlRabiah HK, Al Rashoud SS, Bari A, Wani TA. Khalil NY, et al. Profiles Drug Subst Excip Relat Methodol. 2019;44:333-378. doi: 10.1016/bs.podrm.2018.11.005. Epub 2019 Jan 14. Profiles Drug Subst Excip Relat Methodol. 2019. PMID: 31029222
Topiramate, 2,3:4,5-di-O-isopropylidene-beta-d-fructopyranose sulfamate, is a potent antiepileptic drug with a broad spectrum of activity. It is effective in both partial and generalized seizures. Topiramate was also found to have significant ef …
Topiramate, 2,3:4,5-di-O-isopropylidene-beta-d-fructopyranose sulfamate, is a potent antiepileptic drug with a broad sp …
Topiramate.
[No authors listed] [No authors listed] 2020 Jul 30. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2020 Jul 30. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643944 Free Books & Documents. Review.
Topiramate is a unique antiseizure medication that is widely used in treatment of partial and generalized seizures as well as for bipolar disorder, migraines and weight loss. Topiramate has been rarely associated with hepatic injury and largely when used in c …
Topiramate is a unique antiseizure medication that is widely used in treatment of partial and generalized seizures as well as …
Topiramate.
Glauser TA. Glauser TA. Epilepsia. 1999;40 Suppl 5:S71-80. doi: 10.1111/j.1528-1157.1999.tb00922.x. Epilepsia. 1999. PMID: 10530697 Free article. Review.
Six studies are cited to demonstrate that topiramate is effective as adjunctive therapy for refractory partial-onset seizures in adults. Subsequent studies indicate that topiramate is also effective as monotherapy in adults and as adjunctive therapy for parti …
Six studies are cited to demonstrate that topiramate is effective as adjunctive therapy for refractory partial-onset seizures …
Topiramate: a new antiepileptic drug for refractory epilepsy.
Walker MC, Sander JW. Walker MC, et al. Seizure. 1996 Sep;5(3):199-203. doi: 10.1016/s1059-1311(96)80036-7. Seizure. 1996. PMID: 8902921 Free article. Review.
Topiramate is a recently licensed and marketed antiepileptic drug in the UK for use as add-on therapy for refractory partial epilepsy. ...During long-term treatment, weight loss also occurred and nephrolithiasis occurred in 1.5% of patients receiving topir …
Topiramate is a recently licensed and marketed antiepileptic drug in the UK for use as add-on therapy for refractory pa …
151,803 results
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